It’s pretty hard to narrow down the choices as there are just so many great ones. Mainly sad ones are my faves but some very funny ones too I have to mention.
At the top of my list
AIR - Misuzu’s dying scene “I tried my best, right?..” That just sends me into floods of tears every time, they do such a great job of making you adore Misuzu and then do that to you!
Honourable mention to: Michuru’s final scene on the roof
CLANNAD - just edging out the many is the flower field scene another great tear jerker even though it’s not really sad scene, it’s a special moment.
Honourable mentions to: (anime) Fuko disappears leaving Tomoya and Nagisa asleep together, Fuko and Kouko at the wedding, Kotomi’s breakdown, Akio impassioned speech at Nagisa’s play, Nagisa’s death while ‘Parting at the foot of the hill’ plays, Tomoya’s reconciliation with his father.
Kanon - “Ayu Tsukimiya is no longer in this world”
Honourable mention to Makoto’s wedding, Shiori’s final scene at the fountain, Sayuri’s confession about her brother
Angel Beats! - I never thought I’d choose as pretty much the whole of episode 10 Yui is an annoying genki girl at first, but the ending with “I’d marry you!” and Hinata’s speech while Ichiban… is playing is just wonderful.
Honourable mentions as the numerous members of SSS move on starting with Iwasawa and ‘The Graduation ceremony’ considering there isn’t much time to build a lot of depth for some of them. Plus of course Kanade’s revelation to Yuzuru and his confession of love at the end
Kanon funnies - Ayu in virtually every scene but most of all at the cinema
AIR funnies - “Confession Corner”, The Summer route and the teasing of Lady Kanna
CLANNAD funnies - Just about every scene Sunohara is in, the pranks on Fuko and her general weirdness, The Furukawa family gets drunk
Angel Beats! funnies - Yui’s audition, the rocket chair + Brave Song, Yui’s guitar playing being slated by the band while Yuzuru set up Kanade to do the same
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That’s Part 1, I still have to think about LB!, planetarian and Rewrite…